Protein Agonists, Antagonists and Activators - A-769662 (CAS: 844499-71-4)

A-769662 (CAS: 844499-71-4)

Catalog #：EBC51011

Biological Activity

Synonyms

A769662, A 769662

Chemical Name

6,7-dihydro-4-hydroxy-3-(2′-hydroxy[1,1′-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile

Application

A-769662 is an AMPK activator which induces PI3-kinase-dependent glucose uptake and inhibits AMPK dephosphorylation.

CAS Number

844499-71-4

Purity

≥99.0%

Molecular Weight

360.39

Molecular Formula

C₂₀H₁₂N₂O₃S

SMILES

C1=CC=C(C(=C1)C2=CC=C(C=C2)C3=CSC4=C3C(=C(C(=O)N4)C#N)O)O

Target & IC50

AMPK EC50= 0.8 μM

Shipping

Gel Pack

Storage

Store at 4° C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.7748 ml	13.8739 ml	27.7477 ml
5 mM	0.5550 ml	2.7748 ml	5.5495 ml
10 mM	0.2775 ml	1.3874 ml	2.7748 ml
50 mM	0.0555 ml	0.2775 ml	0.5550 ml

Solubility
DMSO: 36 mg/mL (100 mM) Ethanol: 3.6 mg/mL (10 mM)

Product Description

A-769662 is an AMP-activated protein kinase (AMPK) activator that mimics the function of AMP on AMPK β-1 by allosteric activation and the inhibition of dephosphorylation of AMPK. In the prescence of both LKB1 and A-769662, the phosphorylation of AMPK is suppressed. In addition, A-769662 is not effected by upstream kinases such as calmodulin-dependent protein kinase kinase-β when phosphorylating AMPK beta-1. In vitro tests indicate A-769662 suppresses the activity of Sodium-Potassium Adenosine Triphosphatase by inhibiting the α(1)-isoform of the pump and decreasing the cell surface abundance of the protein complex in skeletal muscle cells and induces glucose uptake through a PI3-kinase-dependent pathway.