Protein Agonists, Antagonists and Activators

AICAR (CAS: 2627-69-2)

Catalog #：EBC51013

Biological Activity

Synonyms

AICA Riboside, Acadesine, AICAR, NSC105823

Chemical Name

5-Amino-1-[(2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl]-1H-imidazole-4-carboxamide

Application

AICAR is an inhibitor of the transcription of PPARα, the coactivation of PPARα

CAS Number

2627-69-2

Purity

≥99.0%

Molecular Weight

258.23

Molecular Formula

C₉H₁₄N₄O₅

SMILES

C1=NC(=C(N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N)C(=O)N

Target & IC50

AMPK, Autophagy

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	3.8725 ml	19.3626 ml	38.7252 ml
5 mM	0.7745 ml	3.8725 ml	7.7450 ml
10 mM	0.3873 ml	1.9363 ml	3.8725 ml
50 mM	0.0775 ml	0.3873 ml	0.7745 ml

Solubility
DMSO: 51 mg/mL (197.50 mM) Water: 20 mg/mL (77.45 mM)

Product Description

AICAR is an adenosine analog that is phosphorylated in whole cells to form 5-aminoimidazole-4-carboxamide-1-D-ribofuranosyl-5′-monophosphate (ZMP), which stimulates AMPK activity1. AICAR acts by entering nucleoside pools, significantly increasing levels of adenosine during periods of ATP breakdown. AICAR mimics the effects of insulin on the expression of two gluconeogenic genes PEPCK and glucose-6-phosphatase2. AICAR inhibits PPARα coactivation3 and adipocyte differentiation4. AICAR is a substrate for the AICAR transformylase activity of ATIC5. AICAR is also known as 5-amino-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide, N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide, and Acadesine.