Protein Inhibitors - AT-406 (CAS: 1071992-99-8)

AT-406 (CAS: 1071992-99-8)

Catalog #：EBC51037

Biological Activity

Synonyms

AT 406, AT406 cpd, SM-406, SM 406, SM406cpd

Chemical Name

(5S,8S,10aR,Z)-N-benzhydryl-5-((Z)-((S)-1-hydroxy-2-(methylamino)propylidene)amino)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carbimidic acid

Application

AT-406 is a potent and orally bioavailable antagonist of multiple inhibitor of apoptosis proteins (IAPs)

CAS Number

1071992-99-8

Purity

≥99.0%

Molecular Weight

561.71

Molecular Formula

C₃₂H₄₃N₅O₄

SMILES

O=C([C@@H]1CC[C@@](CCN(C(CC(C)C)=O)C[C@@H]2NC([C@@H](NC)C)=O)([H])N1C2=O)NC(C3=CC=CC=C3)C4=CC=CC=C4

Target & IC50

XIAP: IC50 = 66.4 nM
cIAP1: IC50 = 1.9 nM
cIAP2: IC50 = 5.1 nM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	1.7803 ml	8.9014 ml	17.8028 ml
5 mM	0.3561 ml	1.7803 ml	3.5606 ml
10 mM	0.1780 ml	0.8901 ml	1.7803 ml
50 mM	0.0356 ml	0.1780 ml	0.3561 ml

Solubility
DMSO: 93 mg/mL (165.6 mM) Ethanol: 93 mg/mL (165.6 mM)

Product Description
AT406 (SM-406, ARRY-334543) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1