Protein Agonists, Antagonists and Activators

U0126 (CAS: 109511-58-2)

Catalog #：EBC51091

Biological Activity

Synonyms

U-0126, U 0126

Chemical Name

2,3-bis[amino[(2-aminophenyl)thio]methylene]-butanedinitrile

Application

U0126 is a highly selective, non-ATP competitive MAP Kinase Kinase (MKK, MEK1 and MEK2) and ERK inhibitor.

CAS Number

109511-58-2

Purity

≥99.0%

Molecular Weight

380.49

Molecular Formula

C₁₈H₁₆N₆S₂

SMILES

NC1=CC=CC=C1S/C(N)=C(C#N)/C(C#N)=C(N)/SC2=CC=CC=C2N

Target & IC50

MEK1: IC50 = 72 nM
MEK2: IC50 = 58 nM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.6282 ml	13.1410 ml	26.2819 ml
5 mM	0.5256 ml	2.6282 ml	5.2564 ml
10 mM	0.2628 ml	1.3141 ml	2.6282 ml
50 mM	0.0526 ml	0.2628 ml	0.5256 ml

Solubility
DMSO: (>10 mg/ml) Ethanol: (2 mg/ml)

Product Description

U0126 is a selective MAPK and ERK inhibitor, displaying a preference for MEK1 and MEK2. The IC50 value for MEK1 is 72nM and MEK2 is 58nM. It is known that U-0126 binds to MAPK noncompetitive manner compared to ATP. Studies suggest that U-0126 antagonizes the transcription of AP-1, via the inhibition of MEK. In addition, U-0126 has been observed to inhibit promoters containing an AP-1 response element. Conversely, U-0126 has no effect on promoters that lack an AP-1 response group. U-0126 is also useful in neuronal studies in mice since it displays inhibitory effects against oxidative stress.