Protein Inhibitors - PD 0325901 (CAS: 391210-10-9)

PD 0325901 (CAS: 391210-10-9)

Catalog #：EBC51043

Biological Activity

Synonyms

PD-0325901, Mirdametinib

Chemical Name

N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide

Application

PD0325901 is a specific and non-ATP-competitive MEK inhibitor

CAS Number

391210-10-9

Purity

≥99.0%

Molecular Weight

482.19

Molecular Formula

C16H14F3In2O4

SMILES

C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOC[C@@H](CO)O

Target & IC50

MEK: IC50 = 0.33nM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.0739 ml	10.3693 ml	20.7386 ml
5 mM	0.4148 ml	2.0739 ml	4.1477 ml
10 mM	0.2074 ml	1.0369 ml	2.0739 ml
50 mM	0.0415 ml	0.2074 ml	0.4148 ml

Solubility
DMSO: 96 mg/mL (199.09 mM)<>Ethanol: 96 mg/mL (199.09 mM)

Product Description

PD 0325901 is a potent and selective MEK1 and MEK2 inhibitor. It is reported to inhibit cell proliferation and arrest cell cycle at the G0/G1 phase of thyroid cancer cells. PD 0325901 can be used with CHIR99021 to reprogram somatic cells into iPS cells and promote cell self-renewal. Studies have shown that in comparison to the CI-1040 MEK inhibitor that PD 0325901 has a greater potency of inhibition, longer duration, greater solubility, improved bioavailability, and increased metabolic stability.