Protein Agonists, Antagonists and Activators

AM 580 (CAS: 102121-60-8)

Catalog #：EBC51060

Biological Activity

Synonyms

CD336, NSC608001, Ro 40-6055

Chemical Name

4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid

Application

AM 580 is a retinoic acid analog and selective RARα agonist

CAS Number

102121-60-8

Purity

≥98.0%

Molecular Weight

351.44

Molecular Formula

C₂₂H₂₅NO₃

SMILES

O=C(O)c1ccc(cc1)NC(=O)c2ccc3c(c2)C(C)(C)CCC3(C)C

Target & IC50

RARα: IC50 = 41 nM
RARβ: EC5050 = 8.6 nM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.8454 ml	14.2272 ml	28.4544 ml
5 mM	0.5691 ml	2.8454 ml	5.6909 ml
10 mM	0.2845 ml	1.4227 ml	2.8454 ml
50 mM	0.0569 ml	0.2845 ml	0.5691 ml

Solubility
DMSO: 45 mg/mL (128.04 mM)

Product Description

AM 580 is a selective retinoic acid analog, which is useful in vitro as a RARα agonist. Studies indicate that RARα increases the signaling of the RARα receptor to prevent intracellular and extracellular amyloid-β accumulation. In addition, this receptor increases the expression of disintegrin and metalloprotease. Since amyloid-β accumulation is a major finding in Alzheimer's disease (AD), AM 580 can be used to study this disease in vitro. AM 580 also induces the functions of IL-4, IL-5 and IL-13 and suppresses the production of IL-12 and IFNγ. Alternate studies suggest that AM 580 inhibits tumor proliferation by reducing the level of RARγ and activates RAR β.