Protein Agonists, Antagonists and Activators - Calcitriol (CAS: 32222-06-3)

Calcitriol (CAS: 32222-06-3)

Catalog #：EBC51071

Biological Activity

Synonyms

RO215535, Topitriol, Rocaltrol, Calcijex, 1,25-Dihydroxyvitamin D3

Chemical Name

(1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol

Application

Calcitriol is the physiologically active form of vitamin D

CAS Number

32222-06-3

Purity

≥99.0%

Molecular Weight

416.64

Molecular Formula

C₂₇H₄₄O₃

SMILES

CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C

Target & IC50

PBMC: IC50 = 0.03 nM
VDR: IC50 = 0.7 nM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.4002 ml	12.0008 ml	24.0015 ml
5 mM	0.4800 ml	2.4002 ml	4.8003 ml
10 mM	0.2400 ml	1.2001 ml	2.4002 ml
50 mM	0.0480 ml	0.2400 ml	0.4800 ml

Solubility
DMSO: 83 mg/mL (199.21 mM) Ethanol: 83 mg/mL (199.21 mM)

Product Description

Calcitriol is the hormonally active metabolite of vitamin D with the addition of three hydroxyl groups. Its main biological effect is to increase the mineralization of bone and the uptake of calcium from the gut into the blood. Calcitriol activates osteoclasts by causing osteoblasts to release Receptor activator of nuclear factor kappa-B ligand (RANKL). It is also reported to exhibit antitumor properties by inhibiting the proliferation of a variety of carcinomas and leukemia cells.