| Biological Activity | |||||||||||||||||||||||||
| Synonyms | AHPN | ||||||||||||||||||||||||
| Chemical Name | 6-(4-Hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid | ||||||||||||||||||||||||
| Application | CD 437 is a cell-permeable RARγ-selective agonist | ||||||||||||||||||||||||
| CAS Number | 125316-60-1 | ||||||||||||||||||||||||
| Purity | ≥99.0% | ||||||||||||||||||||||||
| Molecular Weight | 398.4 | ||||||||||||||||||||||||
| Molecular Formula | C₂₇H₂₆O₃ | ||||||||||||||||||||||||
| SMILES | O=C(O)c1ccc2cc(ccc2c1)c6cc(C5C3CC4CC5CC(C3)C4)c(O)cc6 | ||||||||||||||||||||||||
| Target & IC50 | ADMET: IC50 = 0.33 μM IGROV-1: IC50 = 0.35 μM |
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| Shipping | Gel Pack | ||||||||||||||||||||||||
| Storage | Store at -20°C | ||||||||||||||||||||||||
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| Solubility | |
| DMSO : 150 mg/mL (376.42 mM) |
| Product Description | |
CD 437 is a synthetic, cell-permeable, retinoid-related molecule that induces tumor growth arrest and apoptosis. The exact molecular basis of the underlying mechanism(s) is not yet well understood, however, studies using ovarian adenocarcinoma cells have shown that CD437/AHPN effectively functions as an ER stress inducer. CD 437 is an activator of RAR γ. |
