Protein Agonists, Antagonists and Activators - CH 223191 (CAS: 301326-22-7)

CH 223191 (CAS: 301326-22-7)

Catalog #：EBC51074

Biological Activity

Synonyms

AhR Antagonist, CH223191, AGN-PC-0KP4EW

Application

CH 223191 is a potent and specific aryl hydrocarbon receptor inhibitor

CAS Number

301326-22-7

Purity

≥99.0%

Molecular Weight

333.39

Molecular Formula

C₁₉H₁₉N₅O

SMILES

CC1=CC=CC=C1N=NC2=CC(=C(C=C2)NC(=O)C3=CC=NN3C)C

Target & IC50

TCDD-induced AhR transcription activity: IC50 = 30 nM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.9995 ml	14.9974 ml	29.9949 ml
5 mM	0.5999 ml	2.9995 ml	5.9990 ml
10 mM	0.3000 ml	1.4997 ml	2.9995 ml
50 mM	0.0600 ml	0.2999 ml	0.5999 ml

Solubility
DMSO: 33.3 mg/mL (100 mM) Ethanol: 33.3 mg/mL (100 mM)

Product Description

CH 223191 is a specific and potent antagonist to the aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor that is involved in drug and xenobiotic metabolism. Unlike other AhR antagonists, it does not react with the estrogen receptor and is observed to effect AhR-dependent reporter gene expression in human, mouse, rat, and guinea pig cell lines. CH223191 is reported to exhibit AHR-independent pro-proliferative properties.