Protein Agonists, Antagonists and Activators

CNQX (CAS: 115066-14-3)

Catalog #：EBC51078

Biological Activity

Synonyms

FG-9065, AMPA / kainate antagonist

Chemical Name

6-Cyano-7-nitroquinoxaline-2,3-dione

Application

CNQX is a competitive, non-NMDA glutamate receptor antagonist

CAS Number

115066-14-3

Purity

≥98.0%

Molecular Weight

232.16

Molecular Formula

C₉H₄N₄O₄

SMILES

[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1C#N

Target & IC50

kainate receptor: IC50 = 1.5 μM
AMPA: IC50 = 0.3 μM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	4.3076 ml	21.5378 ml	43.0756 ml
5 mM	0.8615 ml	4.3076 ml	8.6151 ml
10 mM	0.4308 ml	2.1538 ml	4.3076 ml
50 mM	0.0862 ml	0.4308 ml	0.8615 ml

Solubility
DMSO: 30 mg/mL (129.23 mM)

Product Description

CNQX (FG9065) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitive non-NMDA receptor antagonist. Superfusion of hippocampal slices with 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 2-5 microM) reversibly blocked the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow gamma-aminobutyric acid (GABA)-mediated inhibition. CNQX may be a useful antagonist to study excitatory amino acid-mediated synaptic transmission. CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments. The activation of NMDA receptors is sufficient to elicit and maintain fictive locomotion after blockade of non-NMDA receptors with either DNQX or CNQX.