Protein Agonists, Antagonists and Activators - CUR 61414 (CAS: 334998-36-6)

CUR 61414 (CAS: 334998-36-6)

Catalog #：EBC51079

Biological Activity

Synonyms

CUR 61414, CUR61414, G-024586, Hedgehog signaling pathway antagonist

Chemical Name

N-[(3S,5S)-1-(1,3-Benzodioxol-5-ylmethyl)-5-(1-piperazinylcarbonyl)-3-pyrrolidinyl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethylbutanamide

Application

CUR 61414 is a mediator of hedgehog signaling pathways

CAS Number

334998-36-6

Purity

≥98.0%

Molecular Weight

550.69

Molecular Formula

C₃₁H₄₂N₄O₅

SMILES

CC(C)(C)CC(=O)N(CC1=CC(=CC=C1)OC)[C@H]2C[C@H](N(C2)CC3=CC4=C(C=C3)OCO4)C(=O)N5CCNCC5

Target & IC50

Hedgehog inhibitor

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	1.8159 ml	9.0795 ml	18.1590 ml
5 mM	0.3632 ml	1.8159 ml	3.6318 ml
10 mM	0.1816 ml	0.9080 ml	1.8159 ml
50 mM	0.0363 ml	0.1816 ml	0.3632 ml

Solubility
DMSO: 2 mg/mL (clear solution warmed)

Product Description

CUR-61414 is a smoothened receptor antagonist potentially for the treatment of basal cell carcinoma. CUR61414 significantly inhibited skin Hedgehog signaling, blocked the induction of hair follicle anagen, and shrank existing basal cell carcinomas. CUR61414 can suppress proliferation and induce apoptosis of basaloid nests in the basal cell carcinoma model systems, whereas having no effect on normal skin cells.