Photo：010-62890160
| Biological Activity | |||||||||||||||||||||||||
| Synonyms | γ-Secretase inhibitor | ||||||||||||||||||||||||
| Chemical Name | N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-(S)-phenylglycine t-butyl ester | ||||||||||||||||||||||||
| Application | DAPT is a potent and specific inhibitor of γ-secretase | ||||||||||||||||||||||||
| CAS Number | 208255-80-5 | ||||||||||||||||||||||||
| Purity | ≥99.0% | ||||||||||||||||||||||||
| Molecular Weight | 432.46 | ||||||||||||||||||||||||
| Molecular Formula | C₂₃H₂₆F₂N₂O₄ | ||||||||||||||||||||||||
| SMILES | C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F | ||||||||||||||||||||||||
| Target & IC50 | Aβ: IC50 = 115 nM Aβ42: IC50 = 200 nM |
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| Shipping | Gel Pack | ||||||||||||||||||||||||
| Storage | Store at -20°C | ||||||||||||||||||||||||
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| Solubility | |
| DMSO: 86 mg/mL (198.86 mM) Ethanol: 41 mg/mL (94.81 mM) |
| Product Description | |
DAPT is a potent inhibitor of the gamma-secretase complex, which is an internal protease that cleaves single-pass transmembrane proteins at residues within the transmembrane domain. DAPT also indirectly inhibits the Notch protein. It is reported promote neuronal differentiation and enhance the apoptosis of human tongue carcinoma cells. |
