Protein Agonists, Antagonists and Activators - Dexamethasone (CAS: 50-02-2)

Dexamethasone (CAS: 50-02-2)

Catalog #：EBC51085

Biological Activity

Synonyms

DHAP

Chemical Name

(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione

Application

Dexamethasone is a glucocorticoid which induces the production of phospholipase A2 inhibitory protein

CAS Number

50-02-2

Purity

≥99.0%

Molecular Weight

392.46

Molecular Formula

C₂₂H₂₉FO₅

SMILES

O=C1C=C[C@@]2(C)C(CCC3[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@]4(O)C(CO)=O)=C1

Target & IC50

Interleukin receptor

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.5480 ml	12.7402 ml	25.4803 ml
5 mM	0.5096 ml	2.5480 ml	5.0961 ml
10 mM	0.2548 ml	1.2740 ml	2.5480 ml
50 mM	0.0510 ml	0.2548 ml	0.5096 ml

Solubility
DMSO: 78 mg/mL (198.75 mM) Ethanol: 6 mg/mL (15.28 mM)

Product Description

Dexamethasone is an anti-inflammatory glucocorticoid that induces the production of phospholipase A2 inhibitory protein (lipocortin). Dexamethasone also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin A and Cdk2 activity, inhibition of G1/S transition in osteoblasts and inhibition of phosphorylation of Rb protein. Dexamethasone has been observed to induce apoptosis in human thymocytes and eosinophils. Conversely, Dexamethasone has also been observed to inhibit apoptosis in neutrophils.