| Biological Activity | |||||||||||||||||||||||||
| Synonyms | Dibutyryl-cAMP, Bucladesine sodium salt | ||||||||||||||||||||||||
| Chemical Name | sodium (4aR,6S,7R,7aR)-6-(6-butyramido-9H-purin-9-yl)-7-(butyryloxy)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide | ||||||||||||||||||||||||
| Application | Dibutyryl-cAMP, sodium salt is a cell-permable analog of cyclic AMP (cAMP) that stimulates cAMP-dependent protein kinases. | ||||||||||||||||||||||||
| CAS Number | 16980-89-5 | ||||||||||||||||||||||||
| Purity | ≥99.0% | ||||||||||||||||||||||||
| Molecular Weight | 491.37 | ||||||||||||||||||||||||
| Molecular Formula | C₁₈H₂₃N₅NaO₈P | ||||||||||||||||||||||||
| SMILES | CCCC(=O)NC1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@H]4[C@H](O3)COP(=O)(O4)[O-])OC(=O)CCC.[Na+] | ||||||||||||||||||||||||
| Target & IC50 | PKA | ||||||||||||||||||||||||
| Shipping | Gel Pack | ||||||||||||||||||||||||
| Storage | Store at -20°C | ||||||||||||||||||||||||
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| Solubility | |
| DMSO: 49.1 mg/mL (100 mM)
H₂O : 49.1 mg/mL (100 mM) Ethanol：49.1 mg/mL (100 mM) |
| Product Description | |
Dibutyryl-cAMP, sodium salt is an analog of cyclic AMP that stimulates PKA (cAMP-dependent protein kinase). Dibutyryl-cAMP has been shown not to effect cAMP levels, gap junction communication or cumulus expansion in cumulus-oocyte complexes. Research shows that dibutyryl-cAMP can stimulate the activity of Na+, K+-ATPase (Na+,K+-pump), bring about morphological differentiation of astrocytes, and block contraction of vas deferens in rat studies. Additionally, other studies show that Dibutyryl-cAMP can upregulate Nur77 expression through modification of histones during neurite outgrowth in PC-12 cells, and regulate the mRNA levels of Dp71 and dystrophin in rat brain astrocytes. |
