Photo：010-62890160
| Biological Activity | |||||||||||||||||||||||||
| Synonyms | Compound C, AMPK Inhibitor, BML-275 | ||||||||||||||||||||||||
| Chemical Name | 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine | ||||||||||||||||||||||||
| Application | Dorsomorphin is an effective and specific inhibitor of AMPK | ||||||||||||||||||||||||
| CAS Number | 866405-64-3 | ||||||||||||||||||||||||
| Purity | ≥99.0% | ||||||||||||||||||||||||
| Molecular Weight | 399.49 | ||||||||||||||||||||||||
| Molecular Formula | C₂₄H₂₅N₅O | ||||||||||||||||||||||||
| SMILES | C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3 | ||||||||||||||||||||||||
| Target & IC50 | KDR/VEGFR2: IC50 = 25.1 nM ALK2/BMPR-I: IC50 = 148 nM AMPK kinase: IC50 = 234.6 nM |
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| Shipping | Gel Pack | ||||||||||||||||||||||||
| Storage | Store at -20°C | ||||||||||||||||||||||||
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| Solubility | |
| DMSO： 3 mg/mL (7.51 mM) Ethanol： 2 mg/mL (5.01 mM) |
| Product Description | |
Dorsomorphin is a potent and selective inhibitor of the BMP pathway through the ALK2, ALK3, and ALK6 receptors. It is also a selective and reversible inhibitor of the AMP-activated protein kinase (AMPK). Dorsomorphin is reported to be useful in promoting specific cell differentiation and inducing cancer cell line autophagy. |
