Protein Agonists, Antagonists and Activators - Forskolin (CAS: 66575-29-9)

Forskolin (CAS: 66575-29-9)

Catalog #：EBC51097

Biological Activity

Synonyms

Coleonol, Adenylyl cyclase activator

Chemical Name

(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-Dodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyl-1H-benzo[f]chromen-5-yl acetate

Application

Forskolin is an adenylate cyclase activator and MAP kinase inhibitor

CAS Number

66575-29-9

Purity

≥98.0%

Molecular Weight

410.50

Molecular Formula

C₂₂H₃₄O₇

SMILES

CC(=O)O[C@H]2[C@@H](O)[C@@H]1[C@](C)([C@@H](O)CCC1(C)C)[C@@]3(O)C(=O)C[C@](C)(C=C)O[C@]23C

Target & IC50

MAP kinase: IC50 = 25 μM
adenylyl cyclase: IC50 = 41 nM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.4361 ml	12.1803 ml	24.3605 ml
5 mM	0.4872 ml	2.4361 ml	4.8721 ml
10 mM	0.2436 ml	1.2180 ml	2.4361 ml
50 mM	0.0487 ml	0.2436 ml	0.4872 ml

Solubility
DMSO: 30 mg/mL (73 mM) Ethanol: 15 mg/mL (36.5 mM)

Product Description

Forskolin is a diterpenoid isolated from Coleus forskohlii, interacts directly with the catalytic subunit of A cyclase (adenylate cyclase), activating the enzyme and raising intracellular levels of cAMP. Forskolin is cell permeable and active in vivo producing positive inotropic, platelet anti-aggregatory and anti-hypertensive effects in vitro. Has also been shown to exhibit smooth muscle relaxant activity, decrease in intraocular pressure and the promotion of hormonal release from the pituitary glands in vitro. Inhibits MAP kinase, induces phosphorylation of CREB, connexin 43, Bad, ATF-1 and PKB. Forskolin is an inhibitor of AChR.