Protein Inhibitors - GW 9662 (CAS: 22978-25-2)

GW 9662 (CAS: 22978-25-2)

Catalog #：EBC51105

Biological Activity

Synonyms

2-Chloro-5-nitrobenzanilide, GW9662, GW-9662, PPARγ antagonist

Chemical Name

2-chloro-5-nitro-N-phenylbenzamide

Application

GW9662 is a specific PPARγ antagonist

CAS Number

22978-25-2

Purity

≥98.0%

Molecular Weight

276.68

Molecular Formula

C₁₃H₉ClN₂O₃

SMILES

C1=CC=C(C=C1)NC(=O)C2=C(C=CC(=C2)[N+](=O)[O-])Cl

Target & IC50

PPARγ: IC50 = 3.3 nM
PPARα: IC50 = 32 nM
PPARδ: IC50 = 2.0 μM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	3.6143 ml	18.0714 ml	36.1428 ml
5 mM	0.7229 ml	3.6143 ml	7.2286 ml
10 mM	0.3614 ml	1.8071 ml	3.6143 ml
50 mM	0.0723 ml	0.3614 ml	0.7229 ml

Solubility
DMSO: 27.7 mg/mL (100 mM)

Product Description

GW 9662 is a selective, irreversible, and effective PPARγ antagonist that also acts as a FXR and PXR agonist. GW 9662 is an irreversible selective antagonist of PPARgamma, which regulates fatty acid storage and glucose metabolism. It is a more potent alternative to the BADGE molecule and is reported to have anticancer properties and to be useful in blocking the differentiation of monocytes to osteoclasts.