Protein Inhibitors - HPI-1 (CAS: 599150-20-6)

HPI-1 (CAS: 599150-20-6)

Catalog #：EBC51108

Biological Activity

Synonyms

ST093553, AC1MFWGY, Hedgehog pathway inhibitor

Chemical Name

2-Methoxyethyl-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate

Application

HPI-1 is A Hedgehog pathway inhibitor; Gli1/Gli2 inhibitor

CAS Number

599150-20-6

Purity

≥98.0%

Molecular Weight

463.52

Molecular Formula

C₂₇H₂₉NO₆

SMILES

CC1=C(C(C2=C(N1)CC(CC2=O)C3=CC=CC=C3OC)C4=CC(=CC=C4)O)C(=O)OCCOC.O

Target & IC50

Shh: IC50 = 1.5 μM
Gli1: IC50 = 6 μM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.1574 ml	10.7870 ml	21.5740 ml
5 mM	0.4315 ml	2.1574 ml	4.3148 ml
10 mM	0.2157 ml	1.0787 ml	2.1574 ml
50 mM	0.0431 ml	0.2157 ml	0.4315 ml

Solubility
Soluble in DMSO to 100 mM and in ethanol to 100 mM

Product Description

HPI-1 is a hedgehog (Hh) signaling inhibitor without significantly effecting Wnt signaling. It inhibits Gli1 and Gli2 induced activation and the proliferation of SmoM2 expressing cell lines. Hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4 and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation). Also inhibits Hh pathway activation.