Protein Inhibitors - PD 81723 (CAS: 132861-87-1)

PD 81723 (CAS: 132861-87-1)

Catalog #：EBC51126

Biological Activity

Synonyms

PD-81723, PD81723

Chemical Name

(2-Amino-4,5-dimethyl-3-thienyl)-[3-(trifluoromethyl)phenyl]methanone

Application

PD 81723 is an allosteric potentiator that increases the functional effects of adenosine and adenosine analogs

CAS Number

132861-87-1

Purity

≥99.0%

Molecular Weight

299.31

Molecular Formula

C₁₄H₁₂F₃NOS

SMILES

CC1=C(SC(=C1C(=O)C2=CC(=CC=C2)C(F)(F)F)N)C

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	3.3410 ml	16.7051 ml	33.4102 ml
5 mM	0.6682 ml	3.3410 ml	6.6820 ml
10 mM	0.3341 ml	1.6705 ml	3.3410 ml
50 mM	0.0668 ml	0.3341 ml	0.6682 ml

Solubility
DMSO: 29.93 mg/mL (100 mM) Ethanol: 29.93 mg/mL (100 mM)

Product Description

PD 81723 is an allosteric potentiator at Adenosine A1-R that acts via agonist-dependent and independent mechanisms. PD 81723 enhances the functional effects of adenosine and adenosine analogs. This compound also inhibits basal and forskolin-stimulated A cyclase (adenylyl cyclase, AC) activity in Adensosine A1-R expressed in CHO cells, possibly via direct potentiation of constitutive receptor activity or by direct inhibition of A cyclase (adenylyl cyclase, AC).