L-161,982 (CAS: 147776-06-5)
Catalog #:EBC51130
Biological Activity
Synonyms L-161982, EP₄ receptor antagonis
Chemical Name N-((4'-((3-butyl-5-oxo-1-(2-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-4(5H)-yl)methyl)-[1,1'-biphenyl]-2-yl)sulfonyl)-3-methylthiophene-2-carboxamide
Application L-161,982 is an EP₄ receptor antagonist
CAS Number 147776-06-5
Purity ≥98.0%
Molecular Weight 654.72
Molecular Formula C₃₂H₂₉F₃N₄O₄S₂
SMILES CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1sccc1C)c1ccccc1C(F)(F)F
Target & IC50 AT1: IC50 = 0.81 nM
Shipping Gel Pack
Storage Store at -20°C
Preparing Stock Solutions Molecular Structure
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 1.5274 ml 7.6368 ml 15.2737 ml
5 mM 0.3055 ml 1.5274 ml 3.0547 ml
10 mM 0.1527 ml 0.7637 ml 1.5274 ml
50 mM 0.0305 ml 0.1527 ml 0.3055 ml
Solubility
Soluble in DMSO (100 mM)
Product Description

L-161,982 is a selective EP4 receptor antagonist that blocks PGE2-induced ERK phosphorylation and cell proliferation. It is reported to inhibit PGE2-induced bone formation in rats and the anti-inflammatory properties of PGE2 in human macrophages. 

For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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