Protein Agonists, Antagonists and Activators

OAC-1 (CAS: 300586-90-7)

Catalog #：EBC51146

Biological Activity

Synonyms

BAS 00287861, OAC1, AC1LG6VC

Chemical Name

N-1H-Pyrrolo[2,3-c]pyridin-5-ylbenzamide

Application

OAC1 is an activator of Oct4

CAS Number

300586-90-7

Purity

≥98.0%

Molecular Weight

237.26

Molecular Formula

C₁₄H₁₁N₃O

SMILES

C1=CC=C(C=C1)C(=O)NC2=NC=C3C(=C2)C=CN3

Target & IC50

OCT4

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	4.2148 ml	21.0739 ml	42.1479 ml
5 mM	0.8430 ml	4.2148 ml	8.4296 ml
10 mM	0.4215 ml	2.1074 ml	4.2148 ml
50 mM	0.0843 ml	0.4215 ml	0.8430 ml

Solubility
DMSO: 23.7 mg/mL (100 mM) Ethanol: 23.7 mg/mL (100 mM)

Product Description

OAC1 is a Octamer-binding transcription factor 4 (Oct4)-activating compound; enhances the iPSC reprogramming efficiency and accelerated the reprogramming process. IC50 value: Target: Oct4 activator in vitro: OAC1 enhances the formation of Oct4-GFP+ colonies and accelerates the dynamics of reprogramming. OAC1 enhanced reprogramming efficiency through a mechanism that is independent of endogenous Oct4 promoter demethylation. OAC1 enhanced reprogramming efficiency through a mechanism that is distinct from suppressing p53-p21 expression. Luciferase assay revealed that OAC1 had no effect on Topflash activity, although BIO activated the Topflash reporter potently. OAC1 functions through a mechanism that is independent of the Wnt signaling.