Protein Inhibitors - PD 98059 (CAS: 167869-21-8)

PD 98059 (CAS: 167869-21-8)

Catalog #：EBC51148

Biological Activity

Synonyms

PD-98059, PD98059

Chemical Name

2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one

Application

PD 98059 is a selective and reversible inhibitor of MAPK-activating enzyme

CAS Number

167869-21-8

Purity

≥99.0%

Molecular Weight

267.28

Molecular Formula

C₁₆H₁₃NO₃

SMILES

O=C1C=C(OC2=CC=CC=C21)C3=CC=CC(OC)=C3N

Target & IC50

MEK1: IC50 = 4 μM
MEK2: IC50 = 50 μM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	3.7414 ml	18.7070 ml	37.4139 ml
5 mM	0.7483 ml	3.7414 ml	7.4828 ml
10 mM	0.3741 ml	1.8707 ml	3.7414 ml
50 mM	0.0748 ml	0.3741 ml	0.7483 ml

Solubility
DMSO: 46 mg/mL (172.10 mM)

Product Description

PD 98059 is a potent, selective and reversible cell permeable inhibitor of MEK-1 (MAPKK1 or MAPKs ) that binds to the inactive form of MEK-1, blocking MEK-1 activation and leading to inhibition of phosphorylation and the activation of MAP kinase. In PC12 pheochromocytoma cells, it produced complete blockage of any increase in MAPK activity (IC50 = 2 μM) produced by nerve growth factor. It has been shown to enhance self-renewal of embryonic stem cells and has been used to unravel the role of the MAPK cascade in biological systems. The compound has been reported to induce GSTA2 (glutathione S-transferase A2) production in H4IIE cells. PD 98059 has also been shown to enhance insulin-mediated increase in glutathione levels as well as, independent of MEK1 inhibition, elevate primary cultured rat hepatocyte glutathione levels.