Protein Agonists, Antagonists and Activators

PMA (CAS: 16561-29-8)

Catalog #：EBC51149

Biological Activity

Synonyms

Phorbol-12-myristate 13-acetate

Chemical Name

20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate

Application

Phorbol-12-Myristate-13-Acetate (PMA) is an activator of ERK/MAPK

CAS Number

16561-29-8

Purity

≥98.0%

Molecular Weight

616.83

Molecular Formula

C₃₆H₅₆O₈

SMILES

CCCCCCCCCCCCCC(O[C@H]([C@H]1C)[C@]2(OC(C)=O)[C@@]([C@@](C=C(CO)C[C@]34O)([H])[C@@]1(O)[C@]4([H])C=C(C)C3=O)([H])C2(C)C)=O

Target & IC50

PKC: EC50 = 11.7 nM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	1.6212 ml	8.1060 ml	16.2119 ml
5 mM	0.3242 ml	1.6212 ml	3.2424 ml
10 mM	0.1621 ml	0.8106 ml	1.6212 ml
50 mM	0.0324 ml	0.1621 ml	0.3242 ml

Solubility
DMSO: 100 mg/mL (162.12 mM) Ethanol: 100 mg/mL (162.12 mM)

Product Description

Phorbol-12-Myristate-13-Acetate (PMA) is a diester of phorbol and is a tumor promoting compound extracted from croton oil. PMA is a reversible, highly potent protein kinase C (PKC) activator in vitro and in vivo at nM concentrations. PMA′s effects on PKC are attributed to its similarity to diacylgylerol, a natural activator of PKC. PMA activates Ca2+-ATPase and potentiates forskolin-induced cAMP formation. PMA has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells. PMA is also known as Phorbol-12-Myristate-13-Acetate, TPA, 12-O-Tetradecanoylphorbol-13-acetate, PKC Activator I, and tetradecanoic acid, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester.