Protein Inhibitors - Pluripotin (CAS: 839707-37-8)

Pluripotin (CAS: 839707-37-8)

Catalog #：EBC51150

Biological Activity

Synonyms

SC1, SC 1, SC-1

Chemical Name

N-(3-(7-(1,3-Dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide

Application

Pluripotin is a dual inhibitor of ERK1 and RasGAP

CAS Number

839707-37-8

Purity

≥99.0%

Molecular Weight

550.54

Molecular Formula

C₂₇H₂₅F₃N₈O₂

SMILES

CN1C(NC2=NC=C3C(N(C)C(N(C4=CC(NC(C5=CC=CC(C(F)(F)F)=C5)=O)=CC=C4C)C3)=O)=N2)=CC(C)=N1

Target & IC50

RSK1: IC50 = 0.5 μM
RSK2: IC50 = 2.5 μM
RSK3: IC50 = 3.3 μM
RSK3: IC50 = 10 μM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	1.8164 ml	9.0822 ml	18.1643 ml
5 mM	0.3633 ml	1.8164 ml	3.6329 ml
10 mM	0.1816 ml	0.9082 ml	1.8164 ml
50 mM	0.0363 ml	0.1816 ml	0.3633 ml

Solubility
DMSO : 100 mg/mL (181.64 mM)

Product Description

Pluripotin is a small molecule shown to sustain self-renewal of mouse embryonic stem (mES) cells. In order to maintain embryonic stem cells in an undifferentiated state, it is typically necessary to use a combination of feeder cells, leukemia inhibitor factor (LIF) and bone morphogenic protein (BMP); Pluripotin allows for stem cell propagation in the absence of these factors. The activity of Pluripotin is mediated by Ras signaling which promotes self-renewal, and inhibition of ERK blocks differentiation.