| Biological Activity | |||||||||||||||||||||||||
| Synonyms | UNII-PB12M2F8KY, Shh Signaling Antagonist VI | ||||||||||||||||||||||||
| Chemical Name | 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine | ||||||||||||||||||||||||
| Application | Purmorphamine is the first small-molecule agonist developed for the protein Smoothened | ||||||||||||||||||||||||
| CAS Number | 483367-10-8 | ||||||||||||||||||||||||
| Purity | ≥98.0% | ||||||||||||||||||||||||
| Molecular Weight | 520.62 | ||||||||||||||||||||||||
| Molecular Formula | C₃₁H₃₂N₆O₂ | ||||||||||||||||||||||||
| SMILES | C1CCC(CC1)N2C=NC3=C2N=C(N=C3NC4=CC=C(C=C4)N5CCOCC5)OC6=CC=CC7=CC=CC=C76 | ||||||||||||||||||||||||
| Target & IC50 | Sonic hedgehog protein: EC5050 = 1 μM Smo: IC50 = 1.5 μM |
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| Shipping | Gel Pack | ||||||||||||||||||||||||
| Storage | Store at -20°C | ||||||||||||||||||||||||
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| Solubility | |
| DMSO : 50 mg/mL (96.04 mM) |
| Product Description | |
Purmorphamine, a purine derivative, has been shown to activate the Hedgehog (Hh) signaling pathway which is important for regulating embryonic patterning, stem cell renewal, and tissue regeneration. Additionally, this compound has been noted to display osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. Similar studies have reported purmorphamine to enhance events related to osteoblast differentiation. Purmorphamine is an activator of Smo. |
