Protein Substrates - Raloxifene hydrochloride (CAS: 82640-04-8)

Raloxifene hydrochloride (CAS: 82640-04-8)

Catalog #：EBC51158

Biological Activity

Synonyms

Raloxifene HCl, Keoxifene

Chemical Name

[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone hydrochloride

Application

Raloxifene hydrochloride is a SERM of ERα and ERβ

CAS Number

82640-04-8

Purity

≥98%

Molecular Weight

510.04

Molecular Formula

C₂₈H₂₇NO₄S•HCl

SMILES

C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O.Cl

Target & IC50

ER α: IC50 = 0.72 nM
ER β: IC50 = 43 nM
MCF7: IC50 = 0.2 nM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	1.9606 ml	9.8032 ml	19.6063 ml
5 mM	0.3921 ml	1.9606 ml	3.9213 ml
10 mM	0.1961 ml	0.9803 ml	1.9606 ml
50 mM	0.0392 ml	0.1961 ml	0.3921 ml

Solubility
DMSO: 25.5 mg/mL (50 mM)

Product Description

Raloxifene hydrochloride is a selective estrogen receptor modulator (SERM), binding to ERα and ERβ. Tissue-dependently blocks or activates estrogen-induced transcription. Exhibits estrogen agonist behavior in bone but acts as an anti-estrogen in breast and uterine tissue. Raloxifene hydrochloride exhibits inhibitory effects of progesterone receptor induction by estrogen in D12 rat hypothalamic cells. Raloxifene hydrochloride is a substrate of Estrogen Receptor.