Resveratrol, a trihydroxystilbene, is derived from various sources and has been studied with regard to numerous applications including reducing serum lipids, inhibition of platelet aggregation, and actions as a chemopreventative agent and antioxidant. Resveratrol has been shown to increase the longevity of yeast as well as having antiproliferative on cancer stem cells. Resveratrol is a specific inhibitor of Cox-1 (cyclooxygenase-1) via inhibition of the hydroperoxidase activity of Cox-1. Resveratrol has also been used extensively in stem cell studies to enhance self-renewal and multipotency of mesencymal stem cells (MSC′s). Numerous studies have been conducted with regard to Resveratrol-modified cardiac stem cells enhancing cardiac healing. Similar studies with bone marrow derived stem cells (BMSCs) have shown that Resveratrol acts as a NF-κB inhibitor to protect MSC-derived chondrocytes. Additional research with Resveratrol used to treat adipose-derived mesenchymal stem cells (ADMSCs) resulted in increased alkaline phosphatase activity and osteocalcin levels; thus enriching the MSC and osteoprogenitor cell populations in cultured ADMSCs.