Antibiotics - Kanamycin Sulfate (CAS: 25389-94-0 )

Kanamycin Sulfate (CAS: 25389-94-0 )

Catalog #：EBC51160

Biological Activity

Synonyms

Kanamycin

Chemical Name

2-(aminomethyl)-6-[4,6-diamino-3-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric acid

Application

Kanamycin sulfate is an aminoglycoside bacteriocidal antibiotic which acts by binding to the bacterial 30S ribosomes.

CAS Number

25389-94-0

Purity

≥98.0%

Molecular Weight

582.58

Molecular Formula

C₁₈H₃₈N₄O₁₅S

SMILES

OS(O)(=O)=O.O[C@H]1[C@](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@@]3([H])O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)([H])O[C@H](CN)[C@@H](O)[C@@H]1O

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	1.7165 ml	8.5826 ml	17.1651 ml
5 mM	0.3433 ml	1.7165 ml	3.4330 ml
10 mM	0.1717 ml	0.8583 ml	1.7165 ml
50 mM	0.0343 ml	0.1717 ml	0.3433 ml

Solubility
Water： 50.0 mg/mL (85.8 mM)

Product Description

The neurons damage of the DCN caused by kanamycin (500 mg/kg/day) is reversible and autophagy is upregulated in the neurotoxic course of kanamycin on DCN through JNK1-mediated phosphorylation of Bcl-2 pathway in rats. The serum BUN and Cr levels are both increased at the 1st day after the period of kanamycin administration. The neurons expressing LC3 are increased at 1, 7 and 14 days after kanamycin administration in comparison to the control group. Kanamycin treatment results in the increase of autophagy in a time-dependent manner. Kanamycin sulfate (5 mg/kg) and sodium ampicillin (10 mg/kg) administered intramuscularly (i.m.) separately, and then together, to five pony mares, and the ampicillin concentration exceeds 5 mg/mL in inflamed synovial fluid for some 2.5 h after injection, and kanamycin sulfate concentration exceeds 2 mg/mL for 7 h in the pony