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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 29 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-FRA1 (Ser265) Rabbit Polyclonal Antibody detects endogenous levels of FRA1 protein only when phosphorylated at Ser265. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
FRA1 also known as FOSL1 is a nuclear phosphoprotein. FRA1 operates through a sophisticated mechanism involving its basic leucine zipper (bZIP) domain. This domain enables FRA1 to form heterodimers with Jun family proteins, creating complexes that bind specific DNA elements to regulate gene expression. FRA1′s significance becomes particularly evident in cancer biology, where dysregulation of FRA1 contributes to cancer progression, notably in aggressive forms like triple-negative breast cancer (TNBC). Beyond cancer, FRA1 serves as a crucial regulator of immune system function, influencing immune cell states and contributing to inflammatory conditions such as arthritis, psoriasis, and cardiovascular diseases. |
| Product Image Gallery | |
 Western blot analysis of extracts on DU145 cells, using Phospho-FRA1 (Ser265) Rabbit Polyclonal Antibody (EAB10767) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 29 kDa; Observed band size: 43 kDa |
