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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 69 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | HNF1α Rabbit Polyclonal Antibody detects endogenous levels of HNF1α protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
HNF1α also known as MODY3, TCF1, HNF1A is a member of the hepatocyte nuclear factor family. HNF1α plays a crucial role in regulating the transcription of genes involved in liver function and development, as well as in other tissues like the kidney and small intestine. HNF1α binds to specific DNA sequences to activate or repress target genes, making HNF1α essential for maintaining metabolic homeostasis and proper organ function. Nuclear localization of HNF1α directly influences the expression of genes critical for glucose metabolism and insulin secretion, thereby impacting overall metabolic health. HNF1α interacts with other transcription factors, such as HNF4α and HNF3β, to form a regulatory network that ensures precise control of gene expression during development and in adult tissues. |
| Product Image Gallery | |
 Western blot analysis of extracts on HepG2, Raw264.7 cells, using HNF1α Rabbit Polyclonal Antibody (EAB10801) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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