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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB | 74 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-SSH3 (Ser37) Rabbit Polyclonal Antibody detects endogenous levels of SSH3 protein only when phosphorylated at Ser37. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
SSH3 also known as Slingshot homolog 3, SSH3L is a 659 amino acid protein that plays a crucial role in regulating actin filament dynamics, which is essential for various cellular processes such as motility, shape, and division. SSH3 is localized in both the nucleus and cytoplasm, allowing SSH3 to interact with key regulatory proteins involved in actin remodeling. SSH3 functions as a protein phosphatase, specifically targeting the ADF/Cofilin family of proteins, which are critical for the rapid depolymerization and disassembly of filamentous actin (F-actin) in response to cellular signals. By dephosphorylating ADF and Cofilin, SSH3 reactivates these proteins, enabling them to effectively regulate actin dynamics and maintain cellular architecture. SSH3 is expressed as five isoforms due to alternative splicing, which may contribute to SSH3′s functional diversity and regulatory mechanisms in different cellular contexts. |
| Product Image Gallery | |
 Western blot analysis of extracts on HuvEc cells, using Phospho-SSH3 (Ser37) Rabbit Polyclonal Antibody (EAB10825) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
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