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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, ELISA | 59 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Sin1 Rabbit Polyclonal Antibody detects endogenous levels of Sin1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Sin1 also known as MAPKAP-1 is a protein that localizes in the nucleus and is involved in several different signal transduction pathways. Sin1 plays a crucial role in cellular signaling, particularly in the nucleus, Sin1 is essential for the regulation of c-Jun N-terminal kinase (JNK) signaling, acting as a scaffold that facilitates interaction between various signaling molecules. Sin1 undergoes phosphorylation in response to cellular stress, which is critical for function in stress response pathways. Sin1 gene transcription increases during cellular injury, highlighting Sin1′s importance in wound healing and cellular recovery processes. Cells lacking Sin1 show increased sensitivity to stress, sterility, and delays in the cell cycle, underscoring Sin1′s vital role in maintaining cellular homeostasis and response to environmental challenges. |
| Product Image Gallery | |
 Western blot analysis of extracts on U2OS cells, using Sin1 Rabbit Polyclonal Antibody (EAB10854) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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