www.ebiocell.com
| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, ELISA | 133 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | SHIP1 Rabbit Polyclonal Antibody detects endogenous levels of SHIP1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
SHIP-1 also known as INPP5D is a member of the inositol polyphosphate-5-phosphatase (INPP5) family. SHIP-1 is an essential SH2-containing inositol phosphatase that plays a critical role in the negative regulation of the PI3K/Akt signaling pathway by dephosphorylating PIP3 to PIP2, thereby modulating key cellular processes such as immune cell activation, proliferation, and survival. This regulation is vital for maintaining immune homeostasis and preventing excessive immune responses that can lead to autoimmune disorders and cancer. SHIP-1 interacts with several important proteins, including the CSF-1 receptor (c-Fms), adaptor proteins like Grb2 and Dok-1, and the p85 subunit of PI3K, facilitating the integration and attenuation of various signaling cascades. |
| Product Image Gallery | |
 Western blot analysis of extracts on HuvEc, Mouse brain cells, using SHIP1 Rabbit Polyclonal Antibody (EAB10862) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
 Immunohistochemical analysis of paraffin-embedded Human tonsil tissue, using SHIP1 Rabbit Polyclonal Antibody (EAB10862) at 1:100 dilution.
|
