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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 44 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-SEK1/MKK4 (Ser80) Rabbit Polyclonal Antibody detects endogenous levels of SEK1/MKK4 only when phosphorylated at Ser80. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
SEK1 also known as MEK4, MKK4, MAP2K4 is a member of the mitogen-activated protein kinase (MAPK) family. SEK1 plays a crucial role in the mitogen-activated protein kinase (MAPK) signaling pathway by specifically activating both p38 and c-Jun N-terminal kinase (JNK) MAP kinases, which are essential for cellular responses to stress, inflammation, and apoptosis. The activation of these kinases is vital for regulating various physiological processes, including cell differentiation, proliferation, and survival, making SEK1 a significant player in cellular signaling networks. Understanding SEK1 function and interactions within the MAPK pathway can provide insights into the mechanisms underlying various diseases, including cancer and neurodegenerative disorders. |
| Product Image Gallery | |
 Western blot analysis of extracts on NIH/3T3 cells, using Phospho-SEK1/MKK4 (Ser80) Rabbit Polyclonal Antibody (EAB10871) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
 Immunohistochemical analysis of paraffin-embedded Human breast carcinoma tissue, using Phospho-SEK1/MKK4 (Ser80) Rabbit Polyclonal Antibody (EAB10871) at 1:100 dilution.
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