www.ebiocell.com
| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 91 | Human, Mouse, Rat, Monkey |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-PTPα (Tyr798) Rabbit Polyclonal Antibody detects endogenous levels of PTPα only when phosphorylated at Tyr798. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
PTPα also known as RPTPα, PTPRA is a member of the protein tyrosine phosphatase (PTP) family. PTPα plays a crucial role in cellular signaling by dephosphorylating and activating Src family tyrosine kinases, which are essential for regulating integrin signaling, cell adhesion, and growth factor responsiveness. PTPα is located in the cell membrane, where PTPα contains an extracellular domain, a single transmembrane segment, and two tandem intracytoplasmic catalytic domains, allowing PTPα to form constitutive dimers that enhance functional capacity. Additionally, PTPα serves as a receptor for the Helicobacter pylori vacuolating cytotoxin, VacA, highlighting PTPα′s importance in both normal cellular functions and pathogenic processes. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela cells treated with Serum, using Phospho-PTPα (Tyr798) Rabbit Polyclonal Antibody (EAB10911) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
Predicted band size: 91 kDa; Observed band size: 145 kDa |
