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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P | 104 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=50-300 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | PRK1 Rabbit Polyclonal Antibody detects endogenous levels of PRK1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
PRK1 also known as PKN1, PKN belongs to the protein kinase C superfamily. PKN plays a crucial role in cellular signaling by acting as a serine/threonine kinase that is activated by fatty acids and is essential for various cellular processes, including the regulation of the cytoskeleton and cell division. PKN′s unique structure, which includes a catalytic domain homologous to the protein kinase C family, allows PKN to interact specifically with Rho GTPases, thereby functioning as a molecular switch that modulates actin dynamics and cytokinesis. PKN′s structural importance lies in facilitating the phosphorylation of target proteins, such as the head-rod domain of neurofilament protein, which is vital for maintaining neuronal integrity and function. PKN′s interaction with other proteins, such as rhophilin and Citron, underscores PKN′s role in orchestrating complex signaling pathways that are critical for cellular responses to external stimuli. |
| Product Image Gallery | |
 Western blot analysis of extracts on HuvEC cells, using PRK1 Rabbit Polyclonal Antibody (EAB10918) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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