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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 166 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-NMDAR2B (Tyr1336) Rabbit Polyclonal Antibody detects endogenous levels of NMDAR2B only when phosphorylated at Tyr1336. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
NMDAR2B also known as GluN2B, GRIN2B is a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. NMDAR2B plays a crucial role in synaptic plasticity and memory function, as GRIN2B is a key component of the NMDA receptor, which is essential for mediating excitatory neurotransmission in the central nervous system. This receptor is unique due to voltage-dependent activation and high permeability to calcium ions, which are vital for various intracellular signaling pathways. The NMDA receptor is composed of multiple subunits, including ε1, ε2, ε3, ε4, and a ζ subunit, with the ε2 subunit being particularly important for receptor assembly and function. Proper functioning of NMDA receptors is critical for processes such as learning and memory, and dysregulation of these receptors has been implicated in several neurological disorders, including Alzheimer′s disease, schizophrenia, and epilepsy. |
| Product Image Gallery | |
 Western blot analysis of extracts on Jurkat cells treated with TNF, using Phospho-NMDAR2B (Tyr1336) Rabbit Polyclonal Antibody (EAB10987) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
Predicted band size: 166 kDa; Observed band size: 150 kDa |
