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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, ELISA | 81 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-Mre11 (Ser676) Rabbit Polyclonal Antibody detects endogenous levels of Mre11 only when phosphorylated at Ser676. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Mre11 is a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, MRE11 functions in the nucleus as a 3′ to 5′ exonuclease and endonuclease, facilitating DNA end processing to promote repair and maintain genomic stability. Nuclear localization ensures rapid response to DNA damage, preventing potential mutations and neoplastic transformations. MRE11 participates in telomere maintenance, highlighting significance in cellular health and longevity. In conjunction with a DNA ligase, Mre11 protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, A431 cells, using Phospho-Mre11 (Ser676) Rabbit Polyclonal Antibody (EAB11925) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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