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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 180 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | LRP6 Rabbit Polyclonal Antibody detects endogenous levels of LRP6 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
LRP6 is a member of the low density lipoprotein (LDL) receptor gene family. LRP6 plays a crucial role in mediating Wnt/β-catenin signaling, a pathway essential for numerous developmental processes such as body axis patterning, central nervous system development, limb formation, and organogenesis. This signaling pathway is vital for maintaining cellular functions and tissue homeostasis, and dysregulation of LRP6 has been implicated in various diseases, including cancer and metabolic disorders. The human LRP6 gene is located on chromosome 12p13.2 and encodes a protein characterized by a unique arrangement of four epidermal growth factor (EGF) repeats and three low-density lipoprotein receptor (LDLR) repeats in its extracellular domain, which are critical for its interaction with Wnt ligands. |
| Product Image Gallery | |
 Western blot analysis of extracts on SH-SY5Y cells, using LRP6 Rabbit Polyclonal Antibody (EAB13820) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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