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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 70 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | XRCC1 Rabbit Polyclonal Antibody detects endogenous levels of XRCC1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
XRCC1 is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. XRCC1 plays a crucial role in the DNA base excision repair pathway, which is essential for maintaining genomic integrity by repairing single-strand breaks in DNA. XRCC1 acts as a scaffold that facilitates the recruitment of various DNA repair proteins, including DNA ligase III and DNA polymerase, thereby ensuring efficient repair processes. The importance of XRCC1 is underscored by its involvement in preventing mutations that could lead to cancer and other genetic disorders. Additionally, defects in XRCC1 can compromise the DNA repair mechanism, leading to increased susceptibility to DNA damage and contributing to the development of various diseases. |
| Product Image Gallery | |
 Western blot analysis of extracts on NIH/3T3, Jurkat cells, using XRCC1 Rabbit Polyclonal Antibody (EAB13122) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
 Immunohistochemistry analysis of paraffin-embedded Human lung carcinoma tissue, using XRCC1 Rabbit Polyclonal Antibody (EAB13122) at 1:100 dilution.
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