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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, IHC-P, IF/ICC, ELISA | 90 | Human |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:1000-5000 IHC-P=1:100-500 IF/ICC=1:100-500 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | ABCB5 Mouse Monoclonal Antibody detects endogenous levels of ABCB5 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
ABCB5(ATP-binding cassette sub-family B member 5) is a critical multi-pass membrane protein composed of 812 amino acids, belonging to the superfamily of ATP-binding cassette transporters. ABCB5 plays a significant role in the cellular transport of various molecules, utilizing energy derived from ATP hydrolysis to facilitate movement of substances across cellular membranes. Notably, ABCB5 is implicated in the development of chemoresistance in malignant melanomas, particularly in conferring resistance to the chemotherapeutic agent doxorubicin. The presence of two isoforms, alpha and beta, resulting from alternative splicing, adds complexity to function and regulation. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, 293T cells, using ABCB5 Mouse Monoclonal Antibody (EAB11923) at 1:2000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
 Immunohistochemical analysis of paraffin-embedded Human breast caricnoma tissue, using ABCB5 Mouse Monoclonal Antibody (EAB11923) at 1:500 dilution.
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