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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 57 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | CDK5RAP3 Rabbit Polyclonal Antibody detects endogenous levels of CDK5RAP3 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
CDK5RAP3 also known as HSF-27 is a protein that has been reported to function in signaling pathways governing transcriptional regulation and cell cycle progression. CDK5RAP3 plays a crucial role in neuronal differentiation, cell proliferation, and DNA repair, making CDK5RAP3 an important target for research in neurobiology and cancer. CDK5RAP3 is primarily located in the cytoplasm and interacts with the Cdk5 activator protein p35, which is essential for activating Cdk5′s enzymatic activity. This interaction is particularly significant during neuronal differentiation, as increased Cdk5 activity is observed at this stage. CDK5RAP3 functions as a regulatory component of the G2/M DNA damage checkpoint, responding to genotoxic stress, and is expressed in various tissues, including the brain, heart, placenta, liver, skeletal muscle, lung, kidney, and pancreas, with overexpression noted in tumor tissues. |
| Product Image Gallery | |
 Western blot analysis of extracts on 293 cells, using CDK5RAP3 Rabbit Polyclonal Antibody (EAB14730) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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