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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 73 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | PRMT5 Rabbit Polyclonal Antibody detects endogenous levels of PRMT5 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
PRMT5(Protein arginine methyltransferase 5) is an enzyme that belongs to the methyltransferase family. PRMT5 plays a crucial role in regulating gene expression and cell proliferation through its function as a type II protein-arginine methyltransferase, which catalyzes symmetrical dimethylation of arginine residues on target proteins. This post-translational modification is essential for spliceosome assembly, a complex responsible for processing pre-mRNA into mature mRNA, as PRMT5 facilitates binding of Sm proteins to small nuclear RNAs (snRNAs). Methylation of Sm proteins by PRMT5 enhances stability and function, thereby influencing splicing processes and impacting gene expression. |
| Product Image Gallery | |
 Western blot analysis of extracts on HL60, A549 cells, using PRMT5 Rabbit Polyclonal Antibody (EAB14802) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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