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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IHC-P, FC | 64 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IP=1:10-100 IHC-P=1:50-200 FC=1:10-100 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | IFNAR1 Rabbit Monoclonal Antibody detects endogenous levels of IFNAR1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
IFNAR1(Interferon alpha/beta receptor 1) also known as IFN-α/βRα is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. IFNAR1 plays a crucial role in the immune response by mediating the effects of type I interferons, which are vital for establishing an antiviral state in cells. IFNAR1 is primarily located on the cell surface, where IFNAR1 binds to interferons α and β, triggering a cascade of intracellular signaling that leads to the activation of genes involved in antiviral defense. The importance of this location cannot be overstated, as IFNAR1 allows for rapid response to viral infections, enabling cells to mount an effective defense. Additionally, IFNAR1 interaction with the cytoplasmic tyrosine kinase JAK1 is essential for signal transduction, further emphasizing the significance of cellular positioning in mediating immune responses. |
| Product Image Gallery | |
 Western blot analysis of extracts on Jurkat cells, using IFNAR1 Rabbit Monoclonal Antibody (EAB21358) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 64 kDa; Observed band size: 90-130 kDa |
