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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IHC-P, IF/ICC, FC | 54 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IP=1:10-100 IHC-P=1:50-200 IF/ICC=1:50-200 FC=1:10-1:100 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | MMP-12 Rabbit Monoclonal Antibody detects endogenous levels of MMP-12 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
MMP-12(Matrix metallopeptidase 12) is a member of the peptidase M10 family of matrix metalloproteinases (MMPs). MMP-12 plays a crucial role in the degradation of elastin, a key component of the extracellular matrix, which is vital for maintaining the structural integrity and elasticity of tissues. MMP-12′s ability to degrade elastin is particularly important in inflammatory disorders, where MMP-12 may facilitate macrophage migration through the epidermal and vascular basement membranes, contributing to tissue remodeling and repair processes. Additionally, MMP-12 gene transcription is differentially regulated by various stimuli such as phorbol ester, lipopolysaccharide, and staphylococcal enterotoxin B, highlighting MMP-12′s involvement in diverse physiological and pathological processes. |
| Product Image Gallery | |
 Western blot analysis of extracts on MCF7, A549, THP-1 cells, using MMP-12 Rabbit Monoclonal Antibody (EAB21798) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 54 kDa; Observed band size: 54,45,22 kDa |
