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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IHC-P | 80 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-200 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | GRK2 Rabbit Monoclonal Antibody detects endogenous levels of GRK2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
GRK2 also known as BARK1, ADRBK1 is a member of the G protein-coupled receptor kinase family of proteins. GRK2 protein plays a crucial role in the regulation of G protein-coupled receptor signaling, which is essential for numerous physiological processes, including vision, taste, and neurotransmission. Located primarily in the cytoplasm and membrane of cells, GRK2 is activated upon receptor stimulation, leading to the phosphorylation of activated receptors. This phosphorylation is vital for the desensitization of receptors, preventing overstimulation and ensuring that cells can respond appropriately to external signals. GRK2 modulation of receptor activity is particularly important in the context of cardiovascular health, as GRK2 helps regulate heart rate and contractility. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, Jurkat, MCF7 cells, using GRK2 Rabbit Monoclonal Antibody (EAB22604) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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