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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IHC-P, IF/ICC | 39 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:1000-5000 IP=1:10-100 IHC-P=1:100-500 IF/ICC=1:100-500 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | MKK3 Rabbit Monoclonal Antibody detects endogenous levels of MKK3 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
MKK3 also known as MEK3, MAP2K3 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. MKK3 plays a crucial role in the activation of the p38 MAP kinase pathway, which is essential for cellular responses to stress and inflammation. By phosphorylating specific threonine and tyrosine residues on p38 MAP kinase, MEK-3 facilitates the transmission of signals that regulate various biological processes, including cell differentiation, apoptosis, and the immune response. The importance of MEK-3 in these pathways highlights MEK-3′s potential as a therapeutic target in diseases characterized by dysregulated MAP kinase signaling, such as cancer and inflammatory disorders. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela cells, using MKK3 Rabbit Monoclonal Antibody (EAB21770) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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