| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IHC-P, IF/ICC | 10 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IP=1:10-100 IHC-P=1:50-200 IF/ICC=1:50-200 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | DYNLL1 Rabbit Monoclonal Antibody detects endogenous levels of DYNLL1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
DYNLL1 also known as DLC8 plays a crucial role in cellular transport mechanisms by interacting with the dynein motor complex, which is essential for the movement of cellular cargo along microtubules. DYNLL1 is particularly important in neuronal function, as DYNLL1 has been shown to interact with nitric oxide synthase 1 (NOS1), thereby influencing nitric oxide production, which is vital for processes such as apoptosis, synaptogenesis, and neuronal development. DYNLL1′s ability to destabilize the NOS1 dimer is significant, as dimerization is necessary for NOS1 activity, highlighting DYNLL1′s regulatory role in nitric oxide signaling pathways. Ubiquitously expressed, DYNLL1 shows high expression levels in the testis and moderate levels in the brain, indicating diverse functional implications across different tissues. |
| Product Image Gallery | |
 Western blot analysis of extracts on MCF7 cells, using DYNLL1 Rabbit Monoclonal Antibody (EAB21814) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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