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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB | 34 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | SirT5 Rabbit Monoclonal Antibody detects endogenous levels of SirT5 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
SirT5(Sirtuin 5) is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. SIRT5 is primarily localized in mitochondria, where SIRT5 plays a significant role in metabolic regulation and may influence aging processes in humans. Mitochondrial localization of SIRT5 enables direct interaction with various metabolic pathways, including fatty acid oxidation and urea cycle. SIRT5 deacetylates specific mitochondrial proteins, modulating their activity and contributing to overall metabolic homeostasis of cells. Suramin can inhibit SIRT5 by disrupting growth factor binding, highlighting SIRT5′s potential as a therapeutic target in metabolic disorders. Two SIRT5 isoforms arise from alternative splicing, further diversifying functional roles within cells. |
| Product Image Gallery | |
 Western blot analysis of extracts on Jurkat cells, using SirT5 Rabbit Monoclonal Antibody (EAB21849) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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