| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 106 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | ApoER2 Rabbit Polyclonal Antibody detects endogenous levels of ApoER2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
ApoER2 also known as Apolipoprotein E receptor 2, LRP8 a member of the low density lipoprotein receptor (LDLR) family. ApoER2 includes other important receptors such as LDL receptor, LRP, megalin, and VLDLR. This family is characterized by a unique structure that includes a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats, and an O-linked sugar domain, which are essential for their function in cellular signaling and lipid metabolism. ApoER2 is predominantly expressed in the brain and placenta, where ApoER2 plays a vital role in mediating the interaction between extracellular Reelin and the cytosolic protein mDab1 (mammalian disabled protein). This interaction is critical for activating a tyrosine kinase signaling pathway that regulates neuronal migration along radial glial fibers during brain development, highlighting ApoER2′s importance in neurodevelopmental processes. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, Rat spleen cells, using ApoER2 Rabbit Polyclonal Antibody (EAB14893) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
|
